![]() By its count, actin filaments are crucial to at least 20 distinct cellular processes in mammals, and it is certain there are more processes to be found (in fact, the lab has found some). The authors have declared no competing interest. The Higgs laboratory is interested in the many ways mammalian cells use actin filaments. We propose that ADA is necessary for rapid glycolytic activation upon mitochondrial impairment, to re-establish ATP production. Henry N Higgss 134 research works with 10629 citations and 11880 reads, including: INF2-mediated actin filament reorganization confers intrinsic resilience. Both peri-mitochondrial actin loss and a 20% ATP decrease occur within 10 min of CK666 treatment in NDUFS4 knock-out cells. Two situations causing chronic reductions in mitochondrial ATP production, ethidium bromide treatment (to deplete mitochondrial DNA) and mutation to the NDUFS4 subunit of complex 1 of the electron transport chain, cause persistent peri-mitochondrial actin filaments of similar morphology to ADA. Founder Member, Secretary, Royal Economic. The Arp2/3 complex inhibitor CK666 or the mitochondrial sodium-calcium exchanger (NCLX) inhibitor CGP37157, applied simultaneously with the ADA stimulus, inhibit both ADA and the glycolytic increase within 5-min, suggesting that ADA is necessary for glycolytic stimulation. Henry HIGGS, economist in the field of Founder Member, Secretary, Royal Economic Society, United Kingdom, 1890, 1892- 1905. Contents 1 Early life 2 Amateur career 3 Professional career 4 Personal life 5 Professional wins (2) 5.1 Korn Ferry Tour wins (1) 5. Treatments that induce ADA include CCCP, antimycin A, rotenone, oligomycin, and hypoxia. Harry Higgs (born December 4, 1991) is an American professional golfer who plays on the PGA Tour. Join Facebook to connect with Henry Higgs and others you may know. Here we show that ADA is necessary for rapid glycolytic activation upon inhibition of mitochondrial ATP production in multiple cells, including mouse embryonic fibroblasts and effector CD8 + T lymphocytes, for which glycolysis is an important source of ATP and biosynthetic molecules. View the profiles of people named Henry Higgs. Little Henry Higgs, now 11 months, loves to splash around in the bath and reach out and touch his toys. ![]() ![]() The consequences of ADA are not fully understood. One rapid response is peri-mitochondrial actin polymerization, termed ADA ( acute damage-induced actin). Mitochondrial damage represents a dramatic change in cellular homeostasis, necessitating rapid responses. Uri Manor, Sadie Bartholomew, Gonen Golani, Eric Christenson, Michael Kozlov, Henry Higgs, James Spudich, Jennifer Lippincott-Schwartz Is a.
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